- 1 - Title : HMOX 1 and GST variants modify attenuation of FEF 25 - 75 - decline due to PM 10 reduction
نویسندگان
چکیده
1 Chronic Disease Epidemiology , Institute of Social and Preventive Medicine, University of Zürich, Switzerland 2 Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland Division of Clinical Chemistry and Biochemistry, University Children's Hospital Zürich, Zürich, Switzerland 4 Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA 5 Institute of Medical Genetics, Division of Medical Molecular Genetics and Gene Diagnostics, University of Zurich, Switzerland 6 Division of Pulmonary Medicine, University Hospital of Zürich, Zürich, Switzerland 7 Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA 8 Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands 9 Division of Pulmonary Medicine, University Hospitals of Geneva, Geneva, Switzerland
منابع مشابه
Decreased PM10 Exposure Attenuates Age-Related Lung Function Decline: Genetic Variants in p53, p21, and CCND1 Modify This Effect
BACKGROUND Decreasing exposure to airborne particulates was previously associated with reduced age-related decline in lung function. However, whether the benefit from improved air quality depends on genetic background is not known. Recent evidence points to the involvement of the genes p53 and p21 and of the cell cycle control gene cyclin D1 (CCND1) in the response of bronchial cells to air pol...
متن کاملRatio between forced expiratory flow between 25% and 75% of vital capacity and FVC is a determinant of airway reactivity and sensitivity to methacholine.
STUDY OBJECTIVE The ratio between forced expiratory flow between 25% and 75% of vital capacity (FEF(25-75)) and FVC is thought to reflect dysanapsis between airway size and lung size. A low FEF(25-75)/FVC ratio is associated with airway responsiveness to methacholine in middle-aged and older men. The current study was designed to assess this relationship in both male and female subjects over a ...
متن کاملParticulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort
BACKGROUND AND OBJECTIVES We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM(2.5) (fine-particulate air pollution of < 2.5 microm in aerodynamic diameter) on heart rate variability (HRV) in a cross-sectional analysis of the Normative Aging Study, an elderly cohort. We have extended this to include...
متن کاملComparison of maximal midexpiratory flow rate and forced expiratory flow at 50% of vital capacity in children.
BACKGROUND The mid-portion of the maximal expiratory flow-volume (MEFV) curve is often described by values of the mean forced expired flow as lung volume decreases from 75% to 25% of vital capacity (ie, forced expiratory flow, midexpiratory phase [FEF(25-75)]). It is common practice to report also forced expired flow at 50% of vital capacity (FEF(50)). STUDY OBJECTIVE To investigate whether F...
متن کاملعملکرد سیستم تنفسی شاغلین یک کارخانه شیشه سازی با آزمونهای اسپیرومتری
ABSTRACT A case study from July 1993 to June 1994 was carried out on the 711 persons of a glassplant workers (case), and 133 persons of a manufacturing foodstuffs workers (control). The purpose of this research is to determine the respiratory function due to free silica exposure. Statistical analysis of the spirometry test (18 parameters) show significant differences between averages of VC, F...
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تاریخ انتشار 2009